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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
43.94
Human Site:
S504
Identified Species:
60.42
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S504
S
K
M
D
V
A
Q
S
E
L
D
I
Y
L
S
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S504
S
K
M
D
V
A
Q
S
E
L
D
I
Y
L
S
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S503
S
K
M
D
V
A
Q
S
E
L
D
I
Y
L
S
Dog
Lupus familis
XP_535848
1288
147094
S504
S
K
M
D
V
A
Q
S
E
L
D
I
Y
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S502
S
K
M
E
V
A
Q
S
E
L
D
I
Y
L
S
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
E461
K
L
E
G
E
L
T
E
E
V
E
M
A
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
E351
G
I
K
N
V
V
R
E
A
L
Q
K
V
E
E
Chicken
Gallus gallus
NP_989849
1274
145838
A475
S
K
M
D
V
A
Q
A
E
L
D
I
Y
L
T
Frog
Xenopus laevis
P50532
1290
146971
S498
S
K
M
D
V
A
Q
S
E
L
D
I
Y
L
S
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S503
S
R
M
D
V
A
Q
S
E
L
D
I
Y
L
S
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
S500
S
R
M
D
L
A
Q
S
E
L
D
I
Y
L
S
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
V755
K
K
Q
S
E
S
E
V
H
L
Q
E
I
K
A
Honey Bee
Apis mellifera
XP_396862
1282
148175
S440
A
A
F
D
I
A
Q
S
E
L
E
L
Y
I
S
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
E510
G
E
A
R
I
A
R
E
D
F
E
D
L
K
K
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
T504
A
E
K
E
A
K
E
T
E
L
M
G
F
Q
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
S446
G
K
L
D
V
A
S
S
E
S
E
L
L
S
K
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
S577
S
Q
I
Q
L
A
E
S
E
L
S
L
L
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
100
N.A.
93.3
6.6
N.A.
13.3
86.6
100
93.3
86.6
13.3
53.3
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
26.6
100
100
100
100
33.3
86.6
40
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
6
6
0
6
77
0
6
6
0
0
0
6
0
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
59
0
0
0
0
6
0
53
6
0
0
0
% D
% Glu:
0
12
6
12
12
0
18
18
83
0
24
6
0
12
12
% E
% Phe:
0
0
6
0
0
0
0
0
0
6
0
0
6
0
0
% F
% Gly:
18
0
0
6
0
0
0
0
0
0
0
6
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% H
% Ile:
0
6
6
0
12
0
0
0
0
0
0
53
6
6
0
% I
% Lys:
12
53
12
0
0
6
0
0
0
0
0
6
0
18
18
% K
% Leu:
0
6
6
0
12
6
0
0
0
83
0
18
18
53
0
% L
% Met:
0
0
53
0
0
0
0
0
0
0
6
6
0
0
0
% M
% Asn:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
6
6
6
0
0
59
0
0
0
12
0
0
6
0
% Q
% Arg:
0
12
0
6
0
0
12
0
0
0
0
0
0
0
6
% R
% Ser:
59
0
0
6
0
6
6
65
0
6
6
0
0
6
53
% S
% Thr:
0
0
0
0
0
0
6
6
0
0
0
0
0
0
6
% T
% Val:
0
0
0
0
59
6
0
6
0
6
0
0
6
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
59
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _